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Zerona Clinical Research

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The Zerona is a low level laser that emits light at a wavelength and frequency that communicates directly with your fat cells stimulating natural bodily processes.  In this case, the laser stimulates the fat cells which increase their metabolism and eventually form a pore and extrude their contents.  This liquid fat can then be picked up by the lymphatic system and processed for removal by the body.  The fat cells continue to extrude fat into the interstitial space up to 24 hours after the treatment, which is why it is important to maintain a healthy and moderately active lifestyle throughout the duration of the program.  The fat-emulsifying abilities of the laser have been used to help thousands of people to create a more pleasing figure for themselves.

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Cold Laser & Low Level Treatment Technology

The following is another example of scientific proof of the Erchonia lasers effect on adipocytes. All of the SEM, TEM, MRI and all other research of this website was done using an Erchonia laser.

The research represented below was done in the US using an Erchonia laser and shows time released photography of one fat cell and its contents being emptied. Please note the cell is still alive. Erchonia only uses its own research to prove its patent pending applications.

Zerona is the first non-invasive body contouring procedure to effectively remove excess fat without the negative side effects associated with surgical methods. Zerona utilizes the same cold laser technology developed by Erchonia, which has been shown to emulsify fat and allow it to move to interstitial space. Although this technology was originally utilized to help assist tumescent liposuction procedures, it was found that the cold laser treatment alone helped patients to reduce inches from their waist, hip and thighs.

The cold laser technology behind the Zerona procedure was shown to exclusively release the cellular contents of fat cells while leaving the capillaries and other cells within the interstitial space intact. The release of the fat cell contents is the result of the disruption of the cell’s membrane. This membrane disruption, called a transitory pore, is the result of low-level laser stimulation.

Prior to laser exposure, fat cells have a regular, cluster shape, as seen in Figure 4. Within minutes of low level laser exposure, fat cells begin to develop transitory pores as indicated by arrows in Figures 6-9. This pore allows the evacuation of the cell’s contents into extracellular space (see Figure 7). Once the contents of the fat cell have been emptied (Fig. 10), they are released into interstitial space where it can be passed through the body during its normal course of detoxification.

Through a double blind, randomized, multi-site and placebo-controlled study, the Zerona procedure is proven to be an effective non-invasive cold laser weight loss and body contouring procedure. On average, patients lost on average 3.64 inches from the circumference of their waist, hip and thighs, whereas the placebo group only lost an average of a half of an inch.

The Zerona cold lasers provide patients with a safer alternative to surgical procedures, which can result in bruising, swelling, and damage to other tissues. There is no need to wear compression garments or bandages with Zerona and since there is no pain, there is no need for anesthesia. Unlike other non-invasive approaches, Zerona low-level lasers do not rely on heating tissue, which can cause discomfort. There is no downtime, so patients can resume their normal activities immediately.

From Theory to Therapy

ZERONA® utilizes the Erchonia® Laser Scanner, the safest and most researched low-level laser in the world. Initially designed and FDA approved for use during liposuction, the non-invasive Erchonia laser is applied to emulsify the adipose tissue and release excess fat into the interstitial space. From there, fat is passed through the body during its normal course of detoxification.

Whether performing traditional liposuction procedures or following the new ZERONA® protocol, physicians can be confident they are treating their patients with the safest and most researched low level laser in the world.

The ZERONA® procedure has been proven through a double-blind, randomized, multi-site and placebo-controlled clinical study in which patients, on average, lost 3.64 inches from their waist, hips, and thighs. These results were dramatic compared to the placebo group, which only lost an average of half an inch over the same time period.

The remarkable images above demonstrate the low-level laser’s ability to emulsify adipose tissue. The pictures highlight the safe collapse of the rigid adipose cell and the secretion of triglycerides and fatty acid from the cell.

How Triglycerides and Fatty Acids Escape

These images show the formation of a transitory pore forming in the bi-lipid membrane of an adipose cell. This pore is the direct result of safe, low-level laser stimulation and the reason why the triglycerides and fatty acids are able to move into the interstitial space. The tiny pore causes no damage to the cell. It simply allows the fatty content to safely evacuate the cell.

The ZERONA® process is well supported by scientific research and analysis. The specification configurations for ZERONA® are:

  • Configuration: 5-3b Line Generated Laser Diode Modules
  • Wavelength: 635nm
  • Modulation Constant Wave (CW)-1,000 Hz
  • Programming: 4 Time Saving Preset Programs
  • Display: 8″ Full Color TFT Touch Panel Control Center
  • Adjustments 44″ Vertical Arm Height Adjustment
  • Power Source 100-240VAC 50-60Hz
  • Chassis: Powder Coated Metal Frame for Ease of Cleaning, 4 Anti-Static Casters (2 Locking)
  • Housing: Thermoformed of Non-Allergen Material/Plastic
  • Accessories 2-Keys, Laser Safety Glasses

Erchonia Body Contouring Clinical Trial

Erchonia’s Body Contouring Clinical Trial Published in Lasers in Surgery and Medicine

McKinney, TX – December 16, 2009 – Erchonia, the leading developer of non-invasive, low level laser healthcare applications, announces today the results of its body contouring clinical trial are being published in Lasers in Surgery and Medicine’s January issue.
Lasers in Surgery and Medicine, the most widely-circulated, peer-reviewed scientific journal dedicated to laser therapy and diagnosis, is publishing the complete results of Erchonia’s recent, double blind, randomized, multi-site and placebo-controlled study. The study revealed that in six treatments with Erchonia’s Zerona laser – without surgery, diet restrictions or any other adjuncts – patients lost an average of 3.65 inches from their waists, hips and thighs.

Results using the Erchonia laser also have been recently published in the Plastic and Reconstructive Surgery, The Aesthetic Surgery Journal, The American Academy of Cosmetic Surgery Journal, and Clinics in Plastic Surgery and Liposuction.

“With this study, Erchonia has set the standard for non-invasive body contouring devices,” comments Steve Shanks, president of Erchonia. “We have been researching the Erchonia laser’s effect on fat cells for about 12 years. This inclusion in the world’s most prestigious laser journal ads even more credibility to our proven science.”

In contrast to high-power, high-heat lasers that are used in various surgical procedures, Erchonialasers produce a low-level, or cold, output that has no thermal effect on the body’s tissue. Instead, the non-invasive laser helps the body absorb fat by stimulating biological function. As fat congregates in interstitial spaces of cells for a certain amount of time, the Erchonia laser stimulates the body to rid itself of that excess fat using the body’s normal processes.

About the clinical trial: Placebo patients were treated with a 635nm L.E.D. The test group was treated with the Erchonia’s Zerona laser. All patients were treated six times over two weeks, for twenty minutes on each side of the body (forty minutes total). Patients were instructed not to restrict their diets. Patients did not feel pain during the non-invasive treatment, did not receive anesthesia, and assumed normal activities after each treatment.

Erchonia pre-submitted the study results to the FDA for comments and set the clinical significance as a reduction of a minimum of 3 inches cumulative of the waist, hips and thighs. The FDA wanted to distinguish between statistically significant and clinically meaningful results which it felt would help with consumer confidence. Erchonia also submitted a 20-patient study on lipid panel reductions during this treatment as a safety measurement. The results of this study will be published at a later date.

The article published in Lasers in Surgery and Medicine represents all of the data that Erchonia submitted to the FDA for market clearance or 510k which Erchonia expects is imminent.

About Erchonia
Erchonia is the global leader in low level laser healthcare applications. Over the last 15 years, Erchonia has been conducting research & development with the world’s leading physicians to advance the science of low level lasers. Prior to market introduction, all Erchonia lasers are proven to be safe and effective through independent clinical trials. Currently thousands of Erchonia’s lasers are used daily to reduce body fat, eliminate pain, accelerate healing, and treat acne.

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Research Articles

Pain Management

Healed by the Light; an article by Jeffery Nelson, MD

Clinical Trial 1

Clinical Trial 2

The Emerging Paradigm of LLLT™

Low Level Laser Therapy

Low Level Laser Therapy (LLLT) – Part 2

Burn/Wound Healing

Lopez Treatment of Large Skin Necrosis Following a Modified Avelar Abdominoplasty

Dermatology Times Article

Langevin Wound Healing Study 1

Langevin Wound Healing Study 2

Pulsed and CW Laser Comparison

Nelson Burn Brochure

Nelson Burn Abstract

Farouk Abstract

Cosmetic Surgery Times – Dr. Lack

Cosmetic Surgery Wound Healing

Bone Healing

3 Weeks Bone Was Healed

Controversial Therapy Keeps Gregory On Ice

Liposuction

Cosmetic Surgery – Dr. Lack

Cosmetic Surgery – 2004 Clinical Study

Dermatology Times – Dr. Butterwick

FDA Clearance

World Congress on Liposuction

Dr. Neira Cosmetic Surgery 2001

Dr. Neira Aesthetic Surgery Journal 2002

Low Level Laser in Liposuction Results

Breast Augmentation

Breast Implant Clinical Study

Low-Level Laser Therapy Effectiveness for Reducing Pain After Breast Augmentation American Journal of Cosmetic Surgery Vol. 26, No. 3, 2009
Robert F. Jackson, MD; Gregory Roche, DO; Todd Mangione, DO

Body Contouring

Low-Level Laser Therapy as a Non-Invasive Approach for Body Contouring:  A Randomized, Controlled Study  Lasers in Surgery Medicine 41: 799-809 (2009)